What is Adenosine and for what Adenosine is used?
Adenosine medication belong to Antiarrhythmic class.
Adenosine slows conduction through atrioventricular (AV) node; can interrupt reentry pathways through AV node and restore normal sinus rhythm. Adenosine may cause bronchoconstriction. Rapidly metabolized intracellularly to adenosine monophosphate or inosine. Inosine is ultimately degraded to uric acid.
How to Take Adenosine
Take Adenosine exactly as prescribed by health care provider. Adenosine is generally available in market in the form of Injection 3 mg/mL . Drug may produce short-lasting heart block. Patients in whom high-level heart block (eg, third-degree) develops after one dose of Adenosine should not receive repeat doses.
Dosage Instructions for Adenosine Drug
Conversion to sinus rhythm of paroxysmal supraventricular tachycardia (PSVT), including that associated with Wolff-Parkinson-White syndrome.
Contraindications for Adenosine Drug
Second- or third-degree AV block or sick sinus syndrome (except in patients with functioning artificial pacemaker); atrial flutter; atrial fibrillation; ventricular tachycardia.
Interactions of Adenosine with other drugs
Caffeine, theophylline: Antagonize effects of adenosine; larger doses of adenosine may be needed.
Carbamazepine: May produce higher degrees of heart block.
Dipyridamole: Potentiates effects of adenosine; smaller doses may be adequate.
What are the Side Effects of Adenosine -
Like other medicines, Adenosine can cause side effects. Some of the more common side effects of Adenosine include
* Facial flushing; headache; chest pain; hypotension.
* Lightheadedness, dizziness, tingling in arms; numbness.
* Nausea.
* Dyspnea; shortness of breath; chest pressure.
Warnings and precautions before taking Adenosine :
* Inform patient before using Adenosine to report the following symptoms to health care provider: facial flushing, headache, shortness of breath, chest pressure, lightheadedness, dizziness, tingling in arms, numbness or nausea.
* The safety and efficay of Adenosine medicine have not been studied in children and adolescents.
* Warn patient to avoid unnecessary exposure to sun and sun lamps while using this medication. Advise patient to use sunscreens and protective clothing over treated areas when exposure cannot be avoided.
* Advise women before using Adenosine to inform health care provider if pregnant, planning to become pregnant, or breastfeeding while taking Adenosine. Insulin is recommended to maintain blood glucose levels during pregnancy. Prolonged severe neonatal hypoglycemia can occur if sulfonylureas are administered at time of delivery.
What if Overdose of Adenosine ?
If you think you or anyone else taken overdose of Adenosine , immediately telephone your doctor or contact your local or regional Poisons Information Centre Seek medical attention immediately. You may need urgent medical attention. Erythema; scaling; dryness; pruritus, skin discomfort, burning, stinging, and irritation; sunburn; acne flares are may be the overdose symptoms of Adenosine.
What if Missed Dose of Adenosine ?
If you miss a dose of Adenosine medicine and you remember within an hour or so, take the dose immediately. If you do not remember until later, skip the dose you missed and go back to your regular schedule. Do not double doses.
Storage Conditions for Adenosine :
Store Adenosine at room temperature. Do not refrigerate Adenosine because crystallization may occur. If crystallization has occurred, dissolve crystals by warming to room temperature.
By: ashu